Integrin alpha2beta1

An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.

Also Known As:

CD49b-CD29; Glycoprotein Ia-IIa; Platelet Membrane Glycoprotein Heterodimer Ia-IIa; VLA-2; Very Late Antigen-2; alpha2beta1Integrin; CD49b CD29; Glycoprotein Ia IIa; Late Antigen-2, Very; Platelet Membrane Glycoprotein Heterodimer Ia IIa; VLA 2; Very Late Antigen 2; alpha2beta1, Integrin

Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - Platelet Membrane Glycoproteins: 1214
        Integrin alpha2beta1: 164
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - Platelet Membrane Glycoproteins: 1214
        Integrin alpha2beta1: 164
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - Platelet Membrane Glycoproteins: 1214
        Integrin alpha2beta1: 164
    - Cell Surface Receptors: 2125
      - Collagen Receptors: 294
        Integrin alpha2beta1: 164
      - Immunologic Receptors: 9
        Integrins: 14304
        Fibronectin Receptors: 37
        Integrin alpha2beta1: 164
        Very Late Antigen Receptors: 8
        Integrin alpha2beta1: 164
        Platelet Membrane Glycoproteins: 1214
        Integrin alpha2beta1: 164
        Laminin Receptors: 515
        Integrin alpha2beta1: 164

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Disease

Drug/Important Bio-Agent (IBA)